Toye et al., 2024. Oncotarget. DOI: 10.18632/oncotarget.28612. PMID: 39018217
- MAPK activation predominantly occurs through genomic alterations in RAS and BRAF.
- BRAF is an effector kinase that functions downstream of RAS and propagates this oncogenic activity through MEK and ERK.
- Across cancers, BRAF alterations include gain of function mutations, copy number alterations, and structural rearrangements.
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