Jones et al., 2017, Neuro-Oncology
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The World Health Organisation (WHO) Classification of the Central Nervous System
Published in 2021, the fifth edition of the WHO Classification of Tumors of the Central Nervous System highlights the role of advances in novel molecular profiling approaches in identifying new CNS tumor types and subtypes.
The changes in CNS tumor classification have been impacted by the improvements in novel diagnostic technologies and the recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (clMPACT-NOW).
Developing on from the fourth edition in 2016, where nucleic acid-based methodologies* clearly contributed towards a shift in CNS tumor classification and diagnosis, the fifth CNS WHO Classification (WHO CNS5) incorporates the powerful impact of recent emergence of DNA methylome profiling* into the classification system.
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A new genomic framework to categorize pediatric acute myeloid leukemia
Umeda et al., 2024, Nature Genetics. DOI: 10.1038/s41588-023-01640-3
Many pediatric-specific driver alterations are underrepresented in the current classification schemas. The study systemically categorized 887 pAML into 23 mutually distinct molecular categories. These included major entities covering 91.4% of the cohort, such as UBTF and BCL11B.
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